Total synthesis of 11-deoxyanthracyclines: 4-Demethoxy-11-deoxydaunomycin, 11-deoxydaunomycin, and their analogues.
نویسندگان
چکیده
منابع مشابه
Structure of 11-deoxydaunomycin bound to DNA containing a phosphorothioate.
The anthracyclines form an important family of cancer chemotherapeutic agents with a strong dependence of clinical properties on minor differences in chemical structure. We describe the X-ray crystallographic solution of the three-dimensional structure of the anthracycline 11-deoxydaunomycin plus d(CGTsACG). In this complex, two drug molecules bind to each hexamer duplex. Both the drug and the ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.3897